Fabrication of Albumin-Based Scaffold via Freeze-Drying Method for Skin Tissue Engineering Applications

The engineering of skin substitutes is now a reality. For patients with skin injuries and burns, expansion of skin cells in laboratory can make the difference between life and death [1,2]. However, cell biologists and bioengineers are still struggling with making complex skin substitutes that canfacilitate their transplantation in large quantities [3]. The goal of this study was to fabricate a novel spongeform proteinous scaffold from egg white albumin. Weinvestigated the physicochemical properties of the scaffold along with in vitro assessment of human dermal fibroblasts with the intention of cytotoxicity evaluation of this skin substitute