Study Parameters Affecting Size Distribution of BSA-Loaded Chitosan Nanoparticles Produced from Electro-Spray Deposition

Micro/Nanoencapsulation has been widely used in the agricultural, food, cosmetics, pharmaceutical and medicalindustries. The electrospray technique has a great potential for microcapsule preparation because of the simplicity of the apparatus, its high productivity and its easy setup [1]. In thisstudy, electrospray deposition (ESD) is employed to prepare chitosan solid nanoparticles for their wide use as the drug delivery carriers. The main objective of this study was toinvestigate the effects of applied voltage, flow rate, chitosan concentration, drug (BSA) concentration, nozzle gauge, andPVA concentration on the physical and morphological properties of the prepared nanoparticles. In order to investigate the effects of theses parameters, statistical experimental design was used.