Mehran Dorostghoal - Department of Biology, Facultyof Science, Shahid ChamranUniversity of Ahvaz, Ahvaz,Iran
Hamid-o-allah Ghaffari - Hematology, Oncology and StemCell Transplantation ResearchCenter, Tehran University of Medical Sciences, Tehran, Iran.
Nahid Shahbazian - Department of Obstetrics andGynecology, Imam KhomeiniHospital, Ahvaz JundishapurUniversity of Medical Sciences,Ahvaz, Iran
Maryam Mirani - Department of Biology, Facultyof Science, Shahid ChamranUniversity of Ahvaz, Ahvaz,Iran.

Background: Endometrial receptivity plays a key role in the establishment ofsuccessful implantation and its impairment may contribute to subfertility and limitthe assisted reproduction techniques (ART) success.Objective: The aim of present study was to investigate endometrial receptivity interms of β3 integrin, calcitonin and plexin-B1 expression in women withunexplained infertility.Materials and Methods: We evaluated expression of β3 integrin, calcitonin andplexin-B1 through mRNA level measurement with real-time RT-PCR, in theendometrium of 16 infertile patients with unexplained infertility and 10 fertilewomen. Endometrial biopsies were collected during a single menstrual cycle onpostovulatory day LH+7 in each subject.Results: Significant differences regarding β3 integrin and calcitonin expressionlevels found between patients with unexplained infertility and the fertile women.Endometrial plexin-B1 expression levels showed no significant difference betweenfertile and infertile women. There were significant correlations between expressionof β3 integrin with calcitonin and plexin-B1 in fertile and infertile women.Conclusion: Reduced in endometrial expression of β3 integrin and calcitonin aloneor together may contribute to unexplained infertility and these genes could accountas the potential molecular markers of infertility

Unexplained Infertility, Implantation, β3 integrin, Calcitonin, Plexin-B1