SEYED JAVAD AHMADI - Nuclear fuel cycle school, Nuclear Science and Technology Research Institute, End of North Karegar Ave. Po. Box: ۱۴۳۹۹۵ ۱ ۱ ۱۳, Tehran, Iran, Tel.: +۹۸ ۰۲۱۸۸۲۰۲۷۳; fax: +۹۸ ۰۲۱ ۸۸۰۲۱۴ ۱۲
SOODEH ISADJADI - Nuclear fuel cycle school, Nuclear Science and Technology Research Institute, End of North Karegar Ave. Po. Box: ۱۴۳۹۹۵ ۱۱۱۳, Tehran, Iran, Tel.: +۹۸ ۰۲۱۸۸۲۰۲۷۳; fax: +۹۸ ۰۲۱ ۸۸۰۲۱۴۱۲
MORTEZA HOSSENPOUR - Department of Energy Engineering, Sharif University of Technology, Azadi Ave. P.O.Box۱ ۱۳۶۵۸۶۳۹, Tehran, Iran

The three-component reaction of malononitrile, aldehydes and N-unsubstituted amidines, is extended to the formation of 4-amino-5-pyrimidinecarbonitrile derivatives. The reaction occurs in water in the presence of CuO nano particles. This method provides a new route to produce pyrimidine derivatives in good to excellent yields.

CuО nano particles; Malononitrile, Aldehydes, Amidines; 4-Amino-5-pyrimidine carbonitriles