THE SYNTHESIS AND ANTBACTERAL ACTIVITY OF SILVERHTYDR0GEL NANOCOMIPOSITE CONTAINING ANTIBIOTICS

Silver has been in use since time immemorial in the form of metallic silver, silver nitrate, for the treatment of burns, wounds and several bacterial infectionsn recent study, we report the synthesis and antibacterial activity of silver nanoparticles embedded in smart poly (N-isopropylacrylamide)-based hydrogel networks. A series of thermo-sensitive poly (N-isopropylacrylamide-methacrylic acidhydroxyethyll methacrylate)P(NIPAAm -MAA-HEM) with various cross-linking ratio have been obtained by cross-linking free radical polymerization of N-isopropylacrylamide (NTPA Am), methacrylic acid and hydroxyethylmethacrylate (HEM) in the presence of triethyleneglycol dimethacrylate DMA as cross-linker. Highly stable and uniformly distributed silver nanoparticles have been obtained wi hydrogel networks via in situ reduction of silver nitrate (AgNO3) using sodium borohydride (NaBH4) as reducing agent. The formation of silver nanoparticles has been confirmed with ultraviolet visible (UV-Vis) spectroscopy.The preliminary antibacterial activity performed to these hydrogel-silver mamocomposites.

Keywords:

Nanocomposite , Hydrogel , Silver nanoparticles , Antibacterial activity , Antibiotic , Scanning electron microscopy