Electrochemical Study of Some Charge-Transfer ComplexesInvolving Amitriptyline and Nortriptyline and Determination of Drugs

Spectrophotometric and electrochemical studies were successfully used in quantitative analysis of Amitriptyline Hydrochloride(ATH) and Nortriptyline Hydrochloride (NTH). Conductometric titration were carried out in equeous solution using iodide anddopamine and serotonine as titrant. Two new methods using spectrophotometry are dascribed for the determination of (ATH) and(NTH) with potassium bromate as the oxidizing agent and acid dyes, Methyl orange and Indigo carmine. Both spectrophotometricmethods are based on the oxidation of mentioned drugs by a known excess of bromate in acid medium and in the presence of excessof bromide followed by estimation of surplus oxidant by reacting with either Indigo carmine (method A) or Methyl orange (methodB) and measuring the absorbance at 609 or 507 nm

Keywords:

Conductometry , Amitriptyline Hydrochloride , Nortriptyline Hydrochloride , Dopamine Hydrochloride , Serotonine Hydrochloride , Iodine