Naser Samadi - Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran
Mahzad Golafshan Yeganeh - Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran

In this study, an oral insulin delivery system, based on Biocompatible and smart pH sensitive Hydrogel (PSH) on to natural polymer nano-cellulose backbones has been designed. PSH is made of mixed acrylic acid and 2-hydroxyethyl methacrylate on the nano-cellulose backbones and has been identified by using FT-IR and SEM methods. Synthetic networks, can sense the pH environment changes and lead to the creation of a swinging distribution pattern. The results show that the main factor influencing the behavior of the hydrogels in drug distribution, is the pH environment, so that the rate of drug release from the hydrogel, within 48 hours in a simulated body environment in SIF with pH= 9 and blood plasma-neutral environment with pH= 7.4, (93%) has been in greater amount of  it’s release in acidic conditions  (SGF with pH= 1.5) and the results have been satisfactory for the preparation of oral insulin.

Drug Delivery, Smart Hydrogel, Oral Insulin, Nano-Cellulose, Biocompatible