The green synthesis of new Spiro derivatives via four component reaction using ionic liquids as a catalyst

A very quick, effective and environmentally moderate process for the combination of new spiro derivatives is desc. These compounds were prepared through domino one-pot and multicomponent condensation reactions of ninhydrin, orthophenydiamine, dialkyl acetylenedicarboxylate and alkyl or aryl isocyanides when there is a as catalyst. Prominent among the advantages of this work is simplework up procedure, good to high product yields with high purity and short reaction times.

Keywords:

Multi-component reaction , Spiro compounds , Isocyanide , Ionic liquids