Bacterial enzymes – Hyaluronidase

Bacterial enzyme ‘Hyaluronidase’ is acomplex polysaccharide degrading enzymethat cleaves â-GlcNAclinkageof Hyaluronate (HA) by âeliminationprocess. It is synthesized by aspectrum of grampositive bacteria whichserve as potential contributors to a multitudeof infectious diseases in human beings.Especially, group A streptococcus bacteria(GAS) have evolved several orders ofmagnitude to attack the host organism andestablish infection. Hyaluronidase ledpathogenic/ infectious cycle is accomplishedthrough a cascade of events where an escapefrom the host.s immunity is very important.In this regard, a variety of factors are utilizedby hyaluronidases which determine thesuccessful bacterial penetration into hosts,like the use of substrate HA and/or it.senveloping capsule as energy source duringHA lysis, genetic variation among thebacterial strains in the form of allelicpolymorphisms, hyaluronidase enzymestructure-driven substrate binding propertiesetc. Previous studies have furnished betterinsights on nucleotide sequences ofhyaluronidase genes andimmunopathogenesis. However, for a betterunderstanding of hyaluronidase associationwith bacteria and overall host-pathogeninteraction, much investigation and literaturesupport is still needed

Keywords:

Enzyme , Hyalloronidase , Bacteria , Substrate