The Association study between signaling pathways of hsa-miR-1273targetom related with (rs61882771) with the incident of Gastric cancer

Cancer caused by cells goes out of correct pathways. This cell can invade to surrounding healthy cells. There are over 100 different types of cancer and all of them classified by the type of cell that affected. Usually malignancy of gastric cancer starting from layer of the stomach. Gastric cancer has been mentioned as a third cause of death in the world. According to the statistical results, we can see the high frequency of gastric cancer in, japan, china, central and South America, Eastern Europe and parts of the middle east. Higher rates usually have been seen group with lower socioeconomic [1,2]. Some signs of this cancer are indigestion or heartburn, vomiting, diarrhea, constipation and having blood in stool. Stomach cancer usually detects in early stage. Each factor that increase the chance of developing cancer is known as a risk factor. Some factors that may increase the risk of stomach cancer Are: Age, gender, bacteria, family history, race, diet, previous surgery, smoke and obesity [3,4,5,6]. Diagnosis of gastric cancer at first are obtained from laboratory tests and biopsy of stomach with endoscopy. In the next step, cancer may be treated with Surgery, radiation therapy, chemotherapy or immunotherapy [7,8] (Figure1).