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Title

Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits

Year: 1396
COI: JR_IJVST-8-2_009
Language: EnglishView: 347
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Authors

Hooman Mesgarani - Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
Jebrail Movaffagh - Targeted Drug Delivery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Hossein Nourani - Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
Javad Behravan - Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract:

The aim of the present study is to investigate the effects of a sustained-release simvastatin in collagen-polyglycolic acid scaffold on bone formation in the rabbit calvarialcritical-sized defect. This study was carried out to examine if maximum bone regeneration with less inflammation would be attained by combining an optimal dose of simvastatin with Collagen-Polyglycolic acid scaffold, which is an osteoconductive biomaterial capable of releasing the drug slowly. To induce critical-sized calvarial defect in the 10 nominated adult New-Zealand rabbits we trephined four holes measured 5-mm-diameter into each head, and filled them with preparations of different doses of simvastatin (0.5 mg, and 1 mg) blended with Collagen-Polyglycolic acid, Scaffold alone or left empty. Five animals were sacrificed after 4 weeks and the rest of them after 8 weeks and examined histologically. Statistical analysis revealed that in the first time frame (the first four weeks), the difference between the control group and the simvastatin 0.5 mg group on one hand and the simvastatin 1 mg group and the control group on the other hand, there were statistically significant difference between (p < 0.05). In the second time frame (the next four weeks), there were statistically significant differences between the simvastatin 0.5 mg group and the control group, and between the scaffold group and the control group (p <0.05). When combined with collagen-polyglycolic scaffold, 0.5 mg simvastatin is the optimal dose for the arousal of the maximum bone regeneration in rabbit calvarial defects without causing inflammation and it could be applied as an effective bone graft material.

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This Paper COI Code is JR_IJVST-8-2_009. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/665773/

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Mesgarani, Hooman and Movaffagh, Jebrail and Nourani, Hossein and Behravan, Javad,1396,Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits,https://civilica.com/doc/665773

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Type of center: دانشگاه دولتی
Paper count: 34,031
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