The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT

Background: Several studies have reported the uncertain role of multi-minerals and vitamins in the prevention of preeclampsia. Objective: The present study aims to investigate the effect of multimineral-vitaminD supplements (calcium, magnesium, zinc and Vitamin D) and vitamins (C+ E) in the prevention of preeclampsia. Materials and Methods: In this randomized clinical trial, 90 pregnant women weredivided into three groups: group A received Ferrous sulfate (1 tablet/day) + onetablet of Claci-care multimineral-vitamin D containing 800mg calcium, 200mg magnesium, 8mg zinc and 400 IU Vitamin D3 per day; group B received Ferroussulfate (1 tablet/day) + 250 mg vitamin C + 55 mg vitamin E; and the controls received only one Ferrous sulfate tablet daily. Results: The incidence of preeclampsia in group A was significantly lower than thecontrol group (p=0.03), while there was no significant difference between group Band controls (p=0.50), as well as groups A and B (p=0.063). The incidence of neonatal complications in the group A was significantly lower than the control group(p=0.01), while there was no significant difference between group B and control (p=0.48). Conclusion: According to the results, calcium, magnesium, and zinc supplementshave a significant effect on the prevention of preeclampsia. In addition, prescription of multimineral-vitamin D during pregnancy can be a low-cost and affordable way to reduce the incidence of preeclampsia in women who are at high risk of preeclampsia

Keywords:

Prevention , Preeclampsia , Calcium , Magnesium , Zinc , Vitamin D , Vitamin C , Vitamin E