Polycystic ovary syndrome and circulating inflammatory markers

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJRM-15-6_008

تاریخ نمایه سازی: 21 فروردین 1397

Abstract:

Background: Human and experimental studies suggest that the sympathetic regulatory drive in the ovary may be unbalanced (hyperactivity) in polycystic ovary syndrome (PCOS). Dysfunctional secretion of interleukin (IL) -1 (α & β) or related cytokines may thus be related to abnormal ovulation and luteinization. Objective: The aim of this study was the evaluation of cytokines’ pattern in PCOS women and discussion about the explanation of cross-talk between two super systems: sympathetic and immune systems and explanation sympatho-excitation and relationship with interleukins. Materials and Methods: In this study, 171 PCOS women aged between 20-40 years were studied. Their body mass index was <28. The patients were divided into two groups: study group (n=85, PCOS women) and control group (n=86 normal women). The blood sample was obtained on the 3rd day of menstruation cycle. IL-17, IL-1α, IL-1β, and Tumor necrosis factor-alpha (TNF-α) concentrations were determined in both groups. Results: The median serum level of IL-1α in the PCOS group was higher than the control group (293.3 and 8.0, respectively, p<0.001). Also, the median serum level of IL-1β was higher than the control group (5.9 and 3.1 respectively). But the median serum of level IL-17 in women with PCOS was significantly lower than the control group (p<0.001). Conclusion: Our results confirm that PCOS is a low-level chronic inflammation

Authors

Farideh Zafari Zangeneh

Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Mehdi Naghizadeh

Noncommunicable Diseases Research, Fasa University of Medical Sciences, Fasa, Iran

Masoumeh Masoumi

Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran