Synthesis, characterization, spectrophotometric investigation, structural study, and antibacterialactivities of a series of new zinc (II) complexes

Zinc is a necessary element playing numerous roles in organisms. It is involved in the synthesis of proteins and DNA [1], because zinc stabilizes the structure of chromatin and affects the replication of DNA and transcription of RNA by regulating the activity of transcription factors of RNA and DNA polymerases [2]. Zinc is identifyed as essential for the activity of a wide range of enzymes, including metalloenzymes such as zinc-peptidases [3], human carbonic anhydrase [4], alkaline phosphatase [5], and is also involved in enzymatic and catalytic processes [6, 7].We have prepared new zinc (II) complexes with amine and iodide ligands. The complexes have been characterized by various physical and chemical techniques. The crystal structures of 1, 2 and 3 confirmed that they are mononuclear distorted tetrahedral complexes. The equilibrium system of [ZnII(4-Mepy)2I2] was monitored spectrophotometrically. The formation constants of the complex and the molar absorptivity spectra of species are calculated by applying hard modeling method of spectrophotometric data. The complexes show relatively moderate activities against bacteria

Keywords:

Antibacterial activities , Crystal structure , Model complex , Spectrophotometric investigation , Zinc (II) complexes