The effect cannabis sativa plant on accumbense shell arena upon anxiety and Amnesia

Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
View: 517

This Paper With 12 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

ASTCONF01_083

تاریخ نمایه سازی: 17 آبان 1396

Abstract:

The present study investigated the role of serotonin (5-HT2) receptors of Accumbens shell (AcbShell) as well as the interaction of AcbShell activity in both structures in a test-retest elevated plus-maze (EPM) assessment in male Wistar rats.Bilateral guide cannulae were implanted to allow microinjection of ACPA, serotonin agonist (α-Methyl-5-hydroxytryptamine maleate) or antagonist (Cinancerine). Pretest, ACPA (0.002 μg/rat) infusions in each site increased the percentage of open-arms time (%OAT), indicating an anxiolytic-like response. Upon retest EPM (no injection), ACPA extended an anxiolytic profile as compared to control group, suggesting an aversive memory impairment. The data showed that similar microinjection of higher dose of α-Methyl-5-hydroxytryptamine maleate (5-HT2 receptor agonist) and Cinancerine (5-HT2 receptor antagonist) did not alter anxiety and amnesia behavior. Moreover, concurrent microinjection of the subthreshold dose of α-Methyl-5-hydroxytryptamine maleate and Cinancerine into AcbShell block anxiolytic-like behaviour and amnesia induced by intra-AcbShell of ACPA in the test or retest days.The obtained data may suggest that AcbShell 5-HT2 receptor involve in anxiolytic-like behaviors and amnesia induced by ACPA responses in the AcbShell.

Keywords:

Accumbens shell , ACPA , 5-HT2 agonist and antagonist , Anxiety and Amnesia

Authors

Marzieh Keramati-Nojedehsadat

Department of Biology, Faculty of Basic Sciences, Farhangian University, Tehran, Iran

Mohammad Nasehi

Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Garmsar Branch, Semnan, Iran