Saadieh Mohajer - Department of Chemistry, University of Mazandaran, Babolsar, Iran.
Robabeh Baharfar - Department of Chemistry, University of Mazandaran, Babolsar, Iran.

The retrievable nanostructure catalyst that we synthesized in previous work, was asserted to be an efficient heterogeneous catalyst in the synthesis of benzothiazepine derivatives through three-component reaction of coumarine-3-carboxylic acid derivatives, 2-aminothiophenol, and alkyl isocyanides at room temperature under mild conditions. The structure of the novel derivatives products was confirmed by FT-IR, 1H and 13C NMR spectroscopy and Mass spectrometry.

benzothiazepine, three-component reaction, synthesis, mild conditions