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Title

Investigating the interaction of several herbal extracts with α-synuclein by surface plasmon resonance

Year: 1396
Publish place:
COI: CBGCONF04_095
Language: EnglishView: 263
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Authors

Shokouh Honarmand - Department of Biochemistry, Faculty of Biological Sciences, Tarbiat modares university
Bahareh Dabirmanesh - Department of Biochemistry, Faculty of Biological Sciences, Tarbiat modares university
Khosro Khajeh - Department of Biochemistry, Faculty of Biological Sciences, Tarbiat modares university

Abstract:

proteins under particular conditions convert into highly ordered fibrillar aggregation from their native conformation; that are described as amyloid fibrils. α-Synuclein is a small natively unfolded protein that its fibrillation is the causative factor of Parkinson’s disease. The previous studies indicate some particular compounds such as flavonoidsare able to prevent the fibril formation. In this study the effect of few herbal extract (Berberis , Quercus robur, Zizyphus vulgaris, Salix aegyptica) that reported containing flavonoids, were investigated on α-Synuclein fibrillation by ThT fluorescence and the results were confirmed by Surface plasmon resonance. Therefore α-Synuclein was expressed, purified and concentrated to 2.2 mg/ml. subsequently the anti-amyloidogenic effects of extracts were analyzed using thiofelavinT (ThT). The results showed that Berberis and Salix aegyptica extract could decrease the ThT fluorescence that represents the fibrillization has been decreased. To confirm these results, Surface plasmon resonance (SPR), a label free biosensor technique was also used.

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This Paper COI Code is CBGCONF04_095. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Honarmand, Shokouh and Dabirmanesh, Bahareh and Khajeh, Khosro,1396,Investigating the interaction of several herbal extracts with α-synuclein by surface plasmon resonance,چهارمین کنفرانس بین المللی پژوهشهای کاربردی در علوم شیمی و زیست شناسی,Tehran,https://civilica.com/doc/686202

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Type of center: دانشگاه دولتی
Paper count: 31,708
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