Gene Expression Detection Of HOXB13:IL17BR In Sentinel Lymph Node Of Primary Breast Cancer Patients WithoutMacrometastasis

Sentinel lymph node micrometstasis detection improves outcome for breast cancer follow up. Theaim of the current study was to identify gene profiles that accurately predicted the outcome ofbreast cancer patients. The HOXB13:IL17B ratio expression status have been evaluated regarding totumor’s features. 50 tumor samples from breast cancer patients were analyzed for the expression of3 genes by quantitative real time PCR (Q-PCR) procedure, Master Mix reaction containing SYBERgreen. Clinically verification for recurrence to distant organs was performed. According to findings,the negative reported lymph nodes for metastasis, had micro metastasis in significant values.There was a significant difference between normal and cancer samples in 3 gene expression marker.A novel gene expression signature predictive of micro metastatic patients was evaluated. In thisassessment, relationship between these gene with tumor’s features that finding clear role for thesegenes with tumor’s outcome, need to be established.