ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

In Silico Analysis Of MiRNA-150 And Its Related Targets In Breast Cancer

Year: 1395
COI: NASTARANCANSER02_095
Language: EnglishView: 239
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Fatemeh Salamat - Zist Fanavary Novin Institute, Isfahan , Iran
Pardis Saadatmand - Zist Fanavary Novin Institute, Isfahan , Iran
Mansoureh Azadeh - Zist Fanavary Novin Institute, Isfahan , Iran
Kamran Gaedi - Cellular And Molecular Biology Division, Department Of Biology, Faculty Of Science, University Of Isfahan, Isfahan ۸۱۷۴۶-۷۳۴۴۱

Abstract:

Background: Breast cancer is the most common cause of cancer death among women worldwide.miRNAs are the large subgroup of non-coding RNAs with 18-25 nucleotides inhibiting the expressionof target genes by means of binding to their 3’UTR. They can also have tumor suppressor oroncogenic role in cell cycle pathways. Recently, relations between breast cancer risks and someSNPs are located in miRNA seeds or 3’UTR of their target, in some populations have been shown.Aberration in signal transduction pathway of Znf350 family in human tumors is a commonphenomenon. Znf350 as an oncogene and also tumor suppressor gene is a member of Znf350 family.miRWalk2 database was used to identify the has-miR-150 predicted target genes. In next step,DAVID database were used to investigate the function and the related signaling pathways ofobtained has-miR-150 target genes. In silico investigation of SNPs in the 3’UTR of Znf350 geneshowed that rs2278414 could alter the binding properties of has- miR-150. Due to bindinginformation of rs2278414 to has-miR-150 based on ฀G, the binding activity of this microRNA (asoncomiR) undergoes respectively; this SNP could act as a good-prognostic factor. It also appearedthat predicted target genes of our microRNA are related to the most probably cancer pathways suchas ERBB SIGNALING PATHWAY and PATHWAYS IN CANCER . Bioinformatically rs2278414 couldhave association with breast cancer, especially with prognosis of patients. Since has-miR-150 bindsto rs2278414 within ZNF350 and based on in silico information this microRNA involves in cancerpathways, it is predicted that the regulation of ZNF350 by hsa-miR-150 influences the developmentof breast cancer.

Paper COI Code

This Paper COI Code is NASTARANCANSER02_095. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/691843/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Salamat, Fatemeh and Saadatmand, Pardis and Azadeh, Mansoureh and Gaedi, Kamran,1395,In Silico Analysis Of MiRNA-150 And Its Related Targets In Breast Cancer,2nd International Nastaran Cancer Symposium,Mashhad,https://civilica.com/doc/691843

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم
این Paper در بخشهای موضوعی زیر دسته بندی شده است:

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support