The Role Of EpCAM In Cancer Progression

Cancer is one of the important causes of death in the word. The main cause of death in cancer isinvasion and metastasis. Tumor invasion and metastasis is a complex process and continuous andinclude multiple steps like Set at the cellular level by cell adhesion molecule (CAM), catabolicenzyme protein, growth factor and various factor of angiogenesis. Ig,CAM , the immunoglobulinsuper family is a large group of cell surface and soluble protein that are involved in the recognition,binding or adhesion process of cell. One CAM is EpCAM (epidermal cell adhesion molecule) thatinvolvement in tumor progression. EpCAM is glycoprotein with the weight of (40KDa) that known asa marker for cancer. EpCAM effects of not sticking include multiple signaling process andmigration, proliferation and differentiation. EpCAM expression is associated with age, tumor site,tumor size, metastasis, lump node . EpCAM expression in esophageal cancer, pancreas, colon,gastric and prostate ca nce r. Expression of EpCAM is an independentan prognostic factor.EpCAM,CD326 is ecological potential inhibition in multiple tumor. T h a t encoded by TACSTD1.Recently EpCAM to become in interested in the study because it is a signal converter and is apotential marker for the onset of cancer cells. EpCAM also known as KSA, ESA, 17-1A, and GAV33-2.Conclusion: EpCAM have biological role in tumor development and progression. As a cell adhesionmolecule EpCAM mediated cell adhesion is hemophilic as a result of metastasis prevent. The overexpression in colorectal cancer cells inhibiting tumor metastasis and invasion. Retells EpCAMinhibits migration and invasion promote inflammation and the innate immune response. EpCAM isdual role in tumor development and should be planning.