The Role Of Curcumin In Cancer Treatment: The Call Of Nature
عنوان مقاله: The Role Of Curcumin In Cancer Treatment: The Call Of Nature
شناسه ملی مقاله: NASTARANCANSER02_165
منتشر شده در دومین سمپوزیوم بین المللی سرطان نسترن در سال 1395
شناسه ملی مقاله: NASTARANCANSER02_165
منتشر شده در دومین سمپوزیوم بین المللی سرطان نسترن در سال 1395
مشخصات نویسندگان مقاله:
Mohammad Ali Emrani - Faculty Of Medicine, Mashhad University Of Medical Sciences (MUMS), Mashhad, Iran
خلاصه مقاله:
Mohammad Ali Emrani - Faculty Of Medicine, Mashhad University Of Medical Sciences (MUMS), Mashhad, Iran
Cancer is one of the leading causes of morbidity and mortality worldwide, with nearly 14 millionnew cases and 8.2 million cancer related deaths in 2012. Available anti – cancer drugs have severeside effects and are also expensive. So, the more researches for identifying new pharmacologicalagents, without this disadvantages, are needed. Curcumin, a polyphenolic compound which derivedfrom Turmeric, is one of such agents. Turmeric is a rhizome from the herb Curcuma Longa. Itspowder has MM % Curcumin that has been shown to be pharmacologically safe compound with a verylow or no toxicity. We searched the PubMed and Google Scholar databases using the search terms:Curcumin, Cancer and Clinical Trial. 15 studies were identified and reviewed. The articles werepublished from 2002 up to 2016. Among studies, There was an emphasis on apoptotic, anti –proliferative and anti – angiogenic properties of Curcumin. It can suppress cell growth and tumorformation by inhibiting several cell signaling pathways such as transcription factors (NF-kB and AP-1), enzymes (COX-2, MMPs), cell cycle arrest (cyclin D1), proliferation (EGFR and Akt), survivalpathways (bcatenin and adhesion molecules), and TNF. Curcumin up-regulates caspase familyproteins and down-regulates anti-apoptotic genes (Bcl-2 and Bcl-XL). Pre – clinical studies in a in avariety of cancer cell lines including breast, cervical, colon, lung, gastric, hepatic, leukemia,melanoma, lymphoma, oral epithelial, ovarian, pancreatic, and prostate have demonstrated thatCurcumin has anti – cancer activity in vitro and in pre – clinical animal models. It s important thatcancerous cells arrested in mitosis due to Curcumin treatment, acquire double – strand DNAdamage. Curcumin also induce apoptosis in cells selectively. Thus using Curcumin as an anti –cancer drug is safe and without side effects. A study showed Curcumin induces cell apoptosis in Non– Small cell lung cancer by increasing the level of intracellular free calcium. NSCLC is responsiblefor nearly 85% of the total lung cancer cases that isn t sensitive to the majority of conventionalcytotoxic treat ments, such as chemotherapy and radiotherapy. In another studies, showed thatCurcumin can suppress the proliferation of both the androgen-dependent prostate cancer cell line,LNCaP, and the androgen-independent DU145 line. And also in a clinical trial on intravaginalapplication of curcumin based capsule or vaginal cream at bed time for 4 weeks has shownremarkable (∼80%) clearance of the virus. HPV is a small DNA tumor virus which has been shown tobe prevalent in about 90% of cervical cancers and M0% of vaginal cancers. Curcumin, A derivative ofturmeric, has great anti – cancer effects, demonstrated by various researches. Although Curcumin –based drugs in near future will play a significant role in healing cancer patients, using turmericpowder as a dietary supplement is an easy way toward cancer treatment and chemoprevention.
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/691909/