Anticancer Effects Of Chrysin On Colon Cancer Cells: DoEn Regulation Of Sall4

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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NASTARANCANSER02_204

تاریخ نمایه سازی: 22 دی 1396

Abstract:

The SALL4/Sall4 is constitutively expressed in human and mice. SALL4 mRNA could be used as amarker for the diagnosis of different cancers. On the other hand, Chrysin has diverse biologicalproperties. Objectives: In our study, the effects of the chrysin Eere investigated on the CT26 coloncancer in vitro and in vivo. Further expression of stem cell marker sall4, Bax Eere analyzed.Antitumor efficacy of chrysin on transplanted CT26 tumor cells in BALB/c mice Eas investigated. Inaddition, mRNA expressions of sall4, Bax Eere analyzed Eith RT-PCR. The in vivo assay revealedremarkable reduction of colon tumor volume in treated mice (8, 10 mg/kg) as compared Eithuntreated mice. RT-PCR elucidated that chrysin attenuated tumor volume Eith sall4 doEnregulation and Bax up regulation. Consequently, it demonstrated that chrysin accomplished anticancereffect on colon cancer cells via apoptosis induction and attenuation the expression of sall4Ehich introduced chrysin as efficient apoptosis based therapeutic agent against colon cancer.

Authors

Malihe Bahadori

Department Of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

Elaheh Amini

PhD, Department Of Animal Biology, Faculty Of Biological Sciences, Kharazmi University, Tehran, Iran

Javad Baharara

Professor, Department Of Biology, Research Center For Animal Development Applied Biology, Mashhad Branch, Islamic Azad University,Mashhad, Iran