Sadegh Shokri - School Of Persian And Complementary Medicine, MUMS, Mashhad, Iran
Mohammad Nazari - School Of Persian And Complementary Medicine, Mashhad University Of Medical Sciences(MUMS), Mashhad, Iran
Ali Taghizadeh - Surgical Oncology Research Center, MUMS, Mashhad, Iran
Mojtaba Mousavi Bazzaz - Department Of Community Medicine,Faculty Of Medicine, MUMS,Mashhad, Iran

Chemotherapy induced nausea and vomiting (CINV) is the most unfavorable side effect and hasnegative effect on quality of life and continuation of chemotherapy. Despite finding new drugs, theproblem still is remain. For controlling of this complication, Persian medicine offer differentoptions. One of them is Persumac; an Iranian traditional medicine remedy. The general objective ofstudy was considering effect of Persumac on resistant CINV. The specific objectives were to assessthe effect of Persumac on number and severity of nausea and vomiting in CINV . This randomized,double blind, cross over clinical trial was carried out on 69 patients with breast cancer and resistantCINV who received outpatient high emetogenic chemotherapy in Imam Reza hospital, Mashhad,Iran from Octobr 2015 to May 2016. Persumac (prepared from Rhus Coriaria and Bunium Persicumboiss) and lactose as placebo were used. Data collection was performed by a three-sectionquestionnaire covering the demographic characters, number and severity of nausea and vomitingand drug status consumption. 80 of 93 eligible patients in stage I(without intervention), completethe study in stageII(Intevention) and 11 of them declined participation for stage III(cross over).Determining of P value of carry over, period and treatment effects demonstrated that confoundingfactors were not affected the results obtained before and after cross over. The mean severity ofnausea in acute phase was in stageI: 4.83 ± 1.40, stage 2: 4.54 ± 2.0 and stage III: 4.15 ± 0.92 in group1 (first Persumac and then lactose in cross over) and in group 2 (first lactose and then Persumac incross over)was respectively 4.83 ± 1.40, 4.54 ± 2.0, 4.15 ± 0.92 with p value of carry over effect: 0.03and period effect: 0.22. Except severity of nausea in acute phase, the mean number and severity ofnausea and vomiting scores significantly decreased in acute and delayed phase of CINV. Insummary, the findings showed that, Iranian traditional medicine remedy may help for controllingof refractory CINV. The functional importance of these findings is that another option is provided tothe therapists for CINV controlling. Additional research in this area and different cancers, patientswith more various features and more complete methodology and tools could be provide appropriatedesign for new research on this topic.