Zahra Mohebbi Dehnavi - Faculty Of Nursing And Midwifery, Isfahan University Of Medical Sciences, Isfahan, Iran

Young women with breast cancer who undergo chemotherapy or radiation therapy are at risk of ovarian failure and infertility (due to the ovarian sensitivity to chemotherapeutic agents includingalkylated drugs and ionizing radiation). In fact, many of these people become infertile after treatment for cancer. Today, with advances in cancer treatment, the potential for successful treatment andsurvival of cancer patients has increased; Therefore, maintaining the quality of life of these people after treatment is very important. One of the important issues with young women with cancer is maintainingtheir fertility. There are limited methods for preserving fertility in these individuals. The aim of this study is to introduce a variety of methods for treating infertility in breast cancer. This study is a reviewstudy. All published articles were collected over the years 2017-1995 from databases, SIDs, Google Scholar, Scopus, Pubmed, Medlib, Magiran, and Science Direct. Comprehensive search with thekeywords of Cancer, Breast, Fertility, Fertility Assistance for Persian articles and their English equivalent for English articles. After reviewing the studies, a total of 26 papers were reviewed. The findings of the study showed that fertilization methods in patients with breast cancer include: ovarian displacement, freezing of adult and immature oocytes, freezing of adult oocytes, immobilization of oocytes and freezing of ovarian tissue. Except for embryo cryopreservation, all methods for maintaining fertility in women are still in the experimental stage; However, most patients are not able to use embryo cryopreservation for various reasons, such as the lack of delay in the onset of cancer treatment, the risk of hormonal stimulation in some cancers, such as breast cancer and loneliness. Also, this method can not be used in children. According to studies, the method of ovarian cortex freezing is more appropriate than the mentioned methods. One of the advantages of this method is the lack of delay in the onset of cancer treatment, and its disadvantages include a significant reduction in follicular density until transplantation into transplanted tissue, the transmission of tumor cells in the event of ovarian tissue involvement into a tumor. Since there are limited methods for maintaining fertility in women with cancer, selecting one of these methods is highly dependent on the age of the patient, the time available before starting treatment, the marital status of a person, the type of cancer and the risk of ovarian involvement in tumor cells.

Breast Cancer, Cancer Symptoms, Cancer Diagnosis, Cancer Prevention, Cell and Cancer