Drug Release and Antimicrobial Properties of Poly(vinyl alcohol) Hydrogel Wound Dressing Containing Drug Loaded Chitosan Nanoparticles
Publish place: International Conference/Workshop of Inter-Islamic Network on Nanotechnology (INN) on Nanotechnology and Nanomedicine
Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NTNM01_022
تاریخ نمایه سازی: 7 اسفند 1396
Abstract:
The main objective of the present work was to investigate the effect of chitosan nanoparticles application on drug release and antimicrobial properties of poly(vinyl alcohol) (PVA) hydrogeles applied as wound dressing. The nanoparticles loaded by tetracycline were prepared by the ionic gelation method. Corresponding to SEM micrographs observation, the average size of the spherical nanoparticles was about 65 nm. The PVA hydrogels with neat tetracycline and the hydrogel samples with the drug loaded nanoparticles were prepared by the irradiation method at different doses (20, 25 and 30 kGy). Based on the physical properties and the drug release intensity, the dose of 25 kGy was determined as the optimum value. The results of drug release studies indicated that use of the drug loaded nanoparticles, instead of the drug, within the hydrogel resulted in a better control of the drug release. Also, the antibacterial properties were significantly more pronounced for the hydrogel sample with the nanoparticles as compared to the one with the drug.
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Authors
m Entezam
Department of Chemical and Polymer Engineering, Faculty of Engineering, Yazd University, Yazd, ۸۹۱۵۸۱–۸۴۱۱,Iran
f Hosseini
Department of Textile and Polymer Engineering, Yazd Branch, Islamic Azad University, Yazd, ۸۹۱۶۵-۱۱۴۵, Iran
n Nasirizadeh
Department of Textile and Polymer Engineering, Yazd Branch, Islamic Azad University, Yazd, ۸۹۱۶۵-۱۱۴۵, Iran