Synthesis of a novel thermo/pH sensitive nanogel for drug releas

Nanogels (NGs) are three-dimensional water soluble cross-linked hydrogel materials in the nanoscale size range with a high loading capacity for guest molecules and act as drug carrier systems. In the present work, a new type of thermo/pH sensitive NG with branched N isopropylacrylamide (NIPAM) and acrylic acid (AA) was prepared. The P (NIPAM-co-AA) NGs exhibited nonoporous structure and spherical particles with diameters about 89 nm as characterized by dynamic light scattering (DLS). Doxorubicin (DOX) loaded P (NIPAM-co-AA) NGs showed thermo/pH dependent releasing behavior: slow drug release at neutral pH and lower temperature but increased significantly in acidic pH and higher temperature, without any burst release. Overall, our results put forth NGs as potential candidates in the development of a new nanocarrier for anti-cancer drug delivery.

Keywords:

Nanogel , thermos sensitive , pH sensitive , drug releas