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Atomistic insights into the Protein-functionalized nanoparticles

عنوان مقاله: Atomistic insights into the Protein-functionalized nanoparticles
شناسه ملی مقاله: IBIS07_092
منتشر شده در هفتمین همایش بیوانفورماتیک ایران در سال 1396
مشخصات نویسندگان مقاله:

S Yasami Khiabani - Department of Biomedical Engineering, AmirKabir University of Technology, Tehran, Iran
H Rahimi - Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
M Golkar - Molecular Parasitology Laboratory, Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran
A Karkhaneh - Department of Biomedical Engineering, AmirKabir University of Technology, Tehran, Iran

خلاصه مقاله:
Protein-functionalized nanoparticles can be used in various pharmaceutical approaches but the choice of nanoparticle size, shape, charge, linking chemistry, protein-labeling site, etc. remains challenging due to their effect on protein structure and function. Here molecular dynamics simulation was used as a functional way to predict atomistic insights into the charge of polystyrene nanoparticle and epidermal growth factor stability as a model of the nanoparticle-protein complex. Our result showed that the epidermal growth factor orientation regarding the conjugation is suitable and the RMSD analysis represents the complex stability during MD simulation

کلمات کلیدی:
Molecular Dynamics, nanoparticle, conjugation, polystyrene, epidermal growth factor

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/712493/