Evaluation of cytotoxicity Effect of Camptothecin onLung Cancer Cell Line (A549)
Publish place: 8th International Breast Cancer Congress
Publish Year: 1391
نوع سند: مقاله کنفرانسی
زبان: English
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ICBCMED08_290
تاریخ نمایه سازی: 29 فروردین 1397
Abstract:
Cancer is a group of more than 100 different diseases. Many components of medicinal plantshavebeenidentifiedthatpossesssubstantialanticancerousproperties.Thispromptedustoinvestigate the effect of Camptothecin derived from (Camptothecaacuminate)onthegrowthoflungcancercell line (A549). The A549 cell line were seeded in 96-well culture plates and then cytotoxiceffect of Camptothecin was studiedonA549celllineat24and48hrsbyNRUassays.Morphologicalstudies were also carried out using invert microscope. Data analysis showedthatCamptothecinhas cytotoxic effect on A549 cell line in 24,48 and 72hrs withIC50=0.19±0.2,0.16±0.2and 0.23 ±0.2μg/ml respectively.Howeverresultshowsnosignificantdifferencesininhibitionpercentageobservedbetween24,48and72hrsofA549cellsexposuretoCamptothecin.Morphologic alanalysisshowedsignificantdifferencebetweencontrolcells(A549cellsunexposedwithCamptothecin) and treated cells withCamptothecin.Inconclusion,ourfindingsindicatethatCamptothecinhas not time dependent cytotoxic effect onA549celllineandcouldbeexploitedaspotentialsourcefor drugs against lung cancer.
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Authors
Sh Javadi
PayameNoorUniversity,Tehran , Iran
A Sarzaeem
PayameNoorUniversity,Tehran , Iran
M Ltfi
PayameNoorUniversity,Tehran , Iran
A Zare Mirakabadi
PayameNoorUniversity,Tehran , Iran