Identification of Double Minute Chromosomes / Homogeneously Staining Regions in malignancies with special references to Breast Carcinoma
عنوان مقاله: Identification of Double Minute Chromosomes / Homogeneously Staining Regions in malignancies with special references to Breast Carcinoma
شناسه ملی مقاله: ICBCMED08_326
منتشر شده در هشتمین کنگره بین المللی سرطان پستان در سال 1391
شناسه ملی مقاله: ICBCMED08_326
منتشر شده در هشتمین کنگره بین المللی سرطان پستان در سال 1391
مشخصات نویسندگان مقاله:
Abolfazl Movafagh - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mahnoosh Rahimi - Shahid Beheshti University of Medical Sciences, Tehran, Iran
خلاصه مقاله:
Abolfazl Movafagh - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mahnoosh Rahimi - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Background: Homogeneously Staining of Regions or Double MinuteChromosomes are autonomously replicating extra-chromosomal elements thatare frequently associated with gene amplification in a variety of differentcancers especially breast cancer.Materials and Methods: The diagnosis of leukemia patients was based oncharacterization of the leukemic cells, obtained from bone marrow cytogenetics.Results: This study report two cases, one with AML-M1, aged 23 years oldfemale, and the other with CML- blast crisis. A 28 years old female associatedwith Double Minute Chromosomes.Conclusions: Most cases of breast arcinoma and acute myeloid leukemia withdmin in the current literature (including our cases) have been diagnosed ashaving acute myeloid leukemia. More detail will be discussed.
کلمات کلیدی: AML, CML, dmin, HSRs, Iran, New case
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/712948/