مشخصات نویسندگان Paper Study of BMI-1 gene expression in breast cancer tumor tissue and its relationship with cilinopathological markers
Background:breast cancer is the most common cancer among women still is that in case of early diagnosis and timely treatment measures, the chances of survival and recovery is very high. therefore, find possible biomarkers comparing diagnostic, prognosis and response to treatment, particularly ones that have a significant impact, it can be a very important role in the physician s decision to start treatment and select the best treatment path is.. Bmi-1 is transcript inhibitor protein of polycamb family which is inhibitor of genes that induce apoptosis.BMI-1 gene as a strong inhibitor of both pathways of Retinoblastoma (pRB) and p53 is known and so the role of this gene in the process of becoming cancer cells is important. So if there is an increase in the expression of this gene in pathological examples compared to adjacent healthy examples of pathological as control is the gene can be viewed as a potential biomarker in predicting the path of the disease.Material and Methods: 70 samples of fresh tissue samples of typical pathological which conclude 45 healthy adjacent pathological samples and 70 turmeric samples, after the surgery of the breast cancer patients was collected and immediately freeze in -70C. Being healthy and pathological specimens collected by a medical practitioner approved by the pathologist.After the extraction of RNA and cDNA synthesis, the method of Real Time PCR gene expression-gene BMI1 and B-actin genes as internal control review housewife.Result:Bmi-1 gene expression changes in breast cancer, in healthy and pathological tissues adjacent tumor comes about. RT-PCR is a product of the expected size of the 210bp matches for pieces of Bmi-1 designed the production. Incremental changes in Bmi-1 expression of tumoraltissue in comparison with the non-tumoraltexture in 80 percent of the surveyed sample view that if reviews of significant statistical relationship can show the likelihood of the introduction of the biomarker gene as a highly anticipated increase. Statistical reviews and definitive results after the completion of tests.Conclusion:BMI-1 gene expression as significant increase in the oncogene genes of pathological tissue than in healthy tissues, various studies have shown. A study on the Iranian population on the bladder tissue, increase the meaningful expression of this gene in the tissues of the bladder tumor comes towards the non-pathological tissue has been reported to Western-blot and Immunohistochemistry techniques also were approved. The increase far higher this gene in pathological tissues in colorectal cancer, lung and larynx is also so far has been reported in other population Due to being The higher the expression of gene in view of pathological samples relative to adjacent healthy is important so sometimes pathological view of adjacent healthy tissue in such genes expression of the tumor may become cancer stage and perhaps for this reason that this tissue oncogenic genetic changes affect the epinephrine and breast cancer. According to these points is very likely that these could be functional genes such as candidate for bio marker suitable for the prognosis and prediction of stages of the progression of breast cancer. The aim of the present study.
breast cancer, BMI-1 oncogene, Biomarker, gene expression
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برای بار اول: (1396, Afkari eidehlo, Banafsheh؛ Fourozandeh Mahjoobi و Mohammadhossein Sanati
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