Publisher of Iranian Journals and Conference Proceedings

Please waite ..
CIVILICAWe Respect the Science
Publisher of Iranian Journals and Conference Proceedings
عنوان
Paper

Study of BMI-1 gene expression in breast cancer tumor tissue and its relationship with cilinopathological markers

تعداد صفحات: 2 | تعداد نمایش خلاصه: 142 | نظرات: 0
سال انتشار: 1396
کد COI Paper: IPMCMED02_021
زبان Paper: Englishglish
متن کامل این Paper منتشر نشده است و فقط به صورت چکیده یا چکیده مبسوط در پایگاه موجود می باشد.
توضیح: معمولا کلیه مقالاتی که کمتر از ۵ صفحه باشند در پایگاه سیویلیکا اصل Paper (فول تکست) محسوب نمی شوند و فقط کاربران عضو بدون کسر اعتبار می توانند فایل آنها را دریافت نمایند.

مشخصات نویسندگان Paper Study of BMI-1 gene expression in breast cancer tumor tissue and its relationship with cilinopathological markers

Banafsheh Afkari eidehlo - Department of biology, faculty of science, NourDanesh institute of higher education, Meymeh, Isfahan, Iran
Fourozandeh Mahjoobi - Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran
Mohammadhossein Sanati - Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran

چکیده Paper:

Background:breast cancer is the most common cancer among women still is that in case of early diagnosis and timely treatment measures, the chances of survival and recovery is very high. therefore, find possible biomarkers comparing diagnostic, prognosis and response to treatment, particularly ones that have a significant impact, it can be a very important role in the physician s decision to start treatment and select the best treatment path is.. Bmi-1 is transcript inhibitor protein of polycamb family which is inhibitor of genes that induce apoptosis.BMI-1 gene as a strong inhibitor of both pathways of Retinoblastoma (pRB) and p53 is known and so the role of this gene in the process of becoming cancer cells is important. So if there is an increase in the expression of this gene in pathological examples compared to adjacent healthy examples of pathological as control is the gene can be viewed as a potential biomarker in predicting the path of the disease.Material and Methods: 70 samples of fresh tissue samples of typical pathological which conclude 45 healthy adjacent pathological samples and 70 turmeric samples, after the surgery of the breast cancer patients was collected and immediately freeze in -70C. Being healthy and pathological specimens collected by a medical practitioner approved by the pathologist.After the extraction of RNA and cDNA synthesis, the method of Real Time PCR gene expression-gene BMI1 and B-actin genes as internal control review housewife.Result:Bmi-1 gene expression changes in breast cancer, in healthy and pathological tissues adjacent tumor comes about. RT-PCR is a product of the expected size of the 210bp matches for pieces of Bmi-1 designed the production. Incremental changes in Bmi-1 expression of tumoraltissue in comparison with the non-tumoraltexture in 80 percent of the surveyed sample view that if reviews of significant statistical relationship can show the likelihood of the introduction of the biomarker gene as a highly anticipated increase. Statistical reviews and definitive results after the completion of tests.Conclusion:BMI-1 gene expression as significant increase in the oncogene genes of pathological tissue than in healthy tissues, various studies have shown. A study on the Iranian population on the bladder tissue, increase the meaningful expression of this gene in the tissues of the bladder tumor comes towards the non-pathological tissue has been reported to Western-blot and Immunohistochemistry techniques also were approved. The increase far higher this gene in pathological tissues in colorectal cancer, lung and larynx is also so far has been reported in other population Due to being The higher the expression of gene in view of pathological samples relative to adjacent healthy is important so sometimes pathological view of adjacent healthy tissue in such genes expression of the tumor may become cancer stage and perhaps for this reason that this tissue oncogenic genetic changes affect the epinephrine and breast cancer. According to these points is very likely that these could be functional genes such as candidate for bio marker suitable for the prognosis and prediction of stages of the progression of breast cancer. The aim of the present study.

کلیدواژه ها:

breast cancer, BMI-1 oncogene, Biomarker, gene expression

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/714096/

کد COI Paper: IPMCMED02_021

نحوه استناد به Paper:

در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined,1396,Study of BMI-1 gene expression in breast cancer tumor tissue and its relationship with cilinopathological markers,دومین کنگره بین المللی پزشکی شخصی,Tehran,,,https://civilica.com/doc/714096

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1396, Afkari eidehlo, Banafsheh؛ Fourozandeh Mahjoobi و Mohammadhossein Sanati)
برای بار دوم به بعد: (1396, Afkari eidehlo؛ Mahjoobi و Sanati)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

Research Info Management

Certificate | Report Paper
این Paper در بخشهای موضوعی زیر دسته بندی شده است:
  • علوم پزشکی > سرطان
  • Export Citation info of this Paper to research management softwares

    علم سنجی و رتبه بندی Paper

    مشخصات مرکز تولید کننده این Paper به صورت زیر است:
    نوع مرکز: nonprofit
    تعداد مقالات: 82
    در بخش علم سنجی پایگاه سیویلیکا می توانید رتبه بندی علمی مراکز دانشگاهی و پژوهشی کشور را بر اساس آمار مقالات نمایه شده مشاهده نمایید.

    New RelatedPapers


    Papers فوق اخیرا در حوزه مرتبط با این Paper به سیویلیکا افزوده شده اند.

    Share this paper

    WHAT IS COI?

    COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.

    Support