The exosomal microRNA as reliable biomarker to early detection of pancreatic cancer

Pancreatic ductal adenocarcinoma(PDAC) is the most common lethal type of pancreatic cancers.PDAC include 80%–90% of all pancreatic solid tumours and unfortunately these patients have the best up to five-year survival if surgery, chemotherapy, and radiation are Prescribed in the first or second pre-metastatic stage of development. Because of the absence of early symptoms and the lack of early detection, this disease has become one of the most lethal cancers because more than 50% of PDA patients are diagnosed in stage IV.So early detection of this cancer has significant effects on patients survival and treatment methods.Today, microRNAs (miRNA), the subjects of transcriptional and post-transcriptional regulation, are introduced as novel biomarkers because they are stable in a body fluid, inexpensive, Noninvasive and more specific.In this study, refer to bioinformatic technics, we aimed to review novel miRNA that can be used as a reliable biomarker for early detection of pancreatic cancer.we collected the newest and relevant article by searched Pancreatic ductal adenocarcinoma, biomarker, microRNA and early detection as keywords in a valid data base such as NCBI and Scopus.The number of articles detected in our study was 48 that screened 12 of them. Afterward, check out the miRNAs in miRBase and miRCancer data base.Notably selected 23 reliable microRNAs such as miR221, miRLET7A1 and miR155 as miRNA panel for PDAC early detection.Based on results, we collected valuable microRNAs as a biomarker to detect pancreatic cancer at the early stage that causes selected accurate treatment methods.

Keywords:

Pancreatic ductal adenocarcinoma , biomarker , microRNA and early detection