Akbari
Tavakoli-Yaraki

It is well-illustrated that the promise of personalized medicine, which is the tailoring of medical treatment to the individual characteristics, needs and preferences of each patient. Clinicians have long observed that patients with similar symptoms may have different illnesses, with different causes; and similarly, that medical interventions may work well in some patients with a disease but not in others with apparently the same disease. Clinically nonfunctioning pituitary adenomas range from those causing significant hypothalamic/pituitary dysfunction and visual field compromise to those being completely asymptomatic, detected either at autopsy or as incidental findings on imaging scans performed for other reasons (often referred to as pituitary incidentalomas). The molecular signaling pathways which are involved in the pathogenesis of nonfunctioning pituitary adenomas would shed light to the reality and complexity of disease and emphasis on the necessity of applying personalized medicine in new world of medication.