Synthesis and characterization ofpolyurethane/gelatin bio adhesive for hemostat after angiography

In order to stop bleeding after angiography, tissue adhesives have received more attention compared to different kinds of sutures. Both polyurethane and gelatin possess the long history of being tissue adhesives. In the present work, a bio-adhesive based on polyurethane and gelatin has been prepared and evaluated. To this end, firstly polyurethane was synthesized, and then blended polyurethane/gelatin samples with varying blend ratios were prepared. Then, synthesized polyurethane and blended bio-adhesives were characterized using many techniques. According to the experimental results, blended sample with 50:50 volume ratio possesses minimum curing time (around 10 min), least gelatin solubility which is reduced 5 level in 50-50 volume ratio blended bio-adhesive in comparison with pure gelatin. Moreover, this specimen reveals appropriate amount of bulk (water absorption about 105%) and also acceptable level of cell viability. According to the experimental findings, it can be concluded that blended polyurethane/gelatin with 50:50 blend ratio merges the benefits of both polymeric fractions and have the potential to be a bio-adhesive to prohibit bleeding after angiography.

Keywords:

Angiography , Bio-adhesive , Polyurethane , Gelatin , Blending