DBU promoted multi-component domino reactions for Synthesis of benzofurans in water
عنوان مقاله: DBU promoted multi-component domino reactions for Synthesis of benzofurans in water
شناسه ملی مقاله: MRSS01_101
منتشر شده در کنگره ملی شیمی ونانو شیمی از پژوهش تا توسعه ملی در سال 1396
شناسه ملی مقاله: MRSS01_101
منتشر شده در کنگره ملی شیمی ونانو شیمی از پژوهش تا توسعه ملی در سال 1396
مشخصات نویسندگان مقاله:
Elham Zarenezhad - Young Research and Elite Club, Darab Branch, Islamic Azad University, Darab, Iran
خلاصه مقاله:
Elham Zarenezhad - Young Research and Elite Club, Darab Branch, Islamic Azad University, Darab, Iran
An efficient three-component strategy for the preparation of fused 2,3-dihydrofuran derivatives was developed with the assistance of N-hetocyclic compound ylide. The synthesis was achieved by reacting phenacyl bromides, Nheterocycles, aromatic aldehydes and cyclic 1,3-dicarbonyl compounds in the presence of a catalytic amount of DBU(1,8-Diazabicyclo(5.4.0)undec-7-ene) as an inexpensive, impressive and readily available catalyst in water under reflux. This strategy provides a rapid and efficient methodology for the preparation of benzofurans in excellent chemo-, regio- and stereoselectivities. This protocol has the advantages of convenient one-pot operation, short reaction times, high isolated yields of the pure products, easy work-up and avoidance of hazardous or toxic catalysts and organic solvents. Furthermore, it can be considered as environmentally friendly
کلمات کلیدی: Multicomponent domino reactions (MDRs), One-pot synthesis, Benzofuran, DBU
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/718196/