Combination Therapy of siRNA and Chemotherapy in Breast Cancer

Breast cancer is a worldwide leading cause of death. The treatment modalities for breast cancer are surgery, hormone therapy, radiotherapy, chemotherapy and antisense therapy (include siRNA).The poor results obtained with single siRNA delivery have encouraged the development of concomitant strategies by use single siRNA with other therapeutic agents like Doxorubicin. Association and synergy between siRNA and doxorubicin also reduce toxicity of doxorubicin because of use in combination with siRNA, that allowing the use a lower dose of doxorubicin, cause improve their therapeutic effect on breast cancer. This method could overcome potential drug resistance by combining agents with different mechanism of action. Combination therapy successfully applied in the treatment of many types of cancer specially breast cancer. In addition, it will also assess these synergistic effects on other types of cancer and in combination with other drugs.

Keywords:

Breast cancer , siRNA , Combination therapy , Doxorubicin