Life style and Breast Cancer

Breast cancer is the most common female cancer worldwide . The lifetime risk of a women being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes. BRCA1 or BRCA2 , the risk of developing breast or ovarian cancer is significantly increased. MATERIAL and METHOD:To present this review article, researcher used Lifestyle and Breast cancer as key words and searched the google scholar, Cochrane library ,Up-to-date and Pub-med sites, and the result was 10 articles, that after study all of them carefully we selected 5 of them, and use their data in this article.Findings: There is some evidence to support a protective role of a healthy body size and of regular physical activity among mutation carriers, particularly during adolescence or early adulthood. Factors which increase the physiologic expression of the normal copy of the BRCA1 or BRCA2 gene and thereby normalize protein levels , contribute to stem cell homeostasis , and/or affect hormone levels, might mitigate the effects of an inherited BRCA mutation. Discussion and Conclusions:The prospect of changing lifestyle for the purpose of preventing breast cancer in high-risk women , complemented by mechanistic evidence, warrants evaluation in large-scale prospective studies