Paniz Sulek - High school student, raheroshd communication of Education, Tehran, Iran
Negin Nematinia - High school student, raheroshd communication of Education, Tehran, Iran
Najme Dehghan - PhD biophysics student, Tarbiat Modares University, Tehran, Iran

Most of the body normal cells in response to stimulation from inside and outside of the body, growth, reproduce and finally die. If the progress happen in a correct and balanced way, body will be healthy and functions normally but when equilibrium of that is disturbed because of different reasons, it’s the start of difficulties. Among women, breast cancer is the most commonest Couse of death among cancers. Bio-drugs like peptides and monoclonal antibodies, are at the highest level of attention and hope for control or treatment of the disease. About 20 percent of the patient are overexpressed HER2 receptor which is involved in signaling pathways which cause uncontrolled growth and reproduction of the cells. Herceptin, a monoclonal antibody is one of the accepted drugs for HER2 over expressed tumors. Here, we tried to find the most important amino acid sequences of Herceptin, which are involved in the interaction. So using ClusPro, we done molecular docking procedure and some short time molecular dynamic simulation on the selected complexes. Our results show that the extracted peptides could be useful to design more efficient bio- drug in comparison to Herceptin

breast cancer, Her2, Herceptin, molecular dynamic simulation, docking