Marzieh Armat - Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Taiebeh Oghabi Bakhshaiesh - Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Saied Hejazi - Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Nasser Samadi - Department of Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

In recent years, numerous researches on sine oculis homeobox genes have revealed the significant regulatory role of them in organogenesis as well as diseases such as tumorigenesis; consequently, it is essential to review the biology of Six1 gene. These functions of Six family genes are primarily based on structure as well as regulatory role of them in response to external or internal stimuli. An indispensible role of this family involved inorganogenesis development has been widely demonstrated since expression of Six family lead to a distinct increase in development of various organs. In addition to this role Six family proteins can either function as a tumorogenesis since they are overexpressed in adult tissues which may lead to metastasis too. This suggests a more complicated elements and factors which involve in activating this pathway. This review describes thefunction and mechanisms of Six family in several diseases, including cancer and possible strategies to apply this family members for diagnostic, prognostic and therapeutic intentions.

Tumorigenesis, Six Family, Diseases