Acute phase protein status in obese breast cancer patients vs. to non-obese ones
Publish place: 11th International Breast Cancer Congress
Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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ICBCMED11_178
تاریخ نمایه سازی: 21 اردیبهشت 1397
Abstract:
Background: It is hypothesized that chronic inflammation is associated with breast cancer development. In this study, we determined the status of total protein, albumin and C-reactive protein (CRP) in obese breast cancer patients vs. to normal weight ones. Methods and Materials: In this cross-sectional study, among breast cancer patients (stage II-III) who were treated previously and referred to the Shahid Rajaee hospital (Babolsar, Mazandaran) for routine follow-up, 45 obese patients (body mass index (BMI) ≥25 kg/m2) and 30 normal weight ones (18.5≤ BMI <25 kg/m2) were selected. Serum levels of total protein and albumin were measured with spectrophotometric method. CRP levels were determined by latex immunoturbidimetric assay. And the resulted data were compared by independent T-test via SPSS software. Results:Lower serum albumin and higher CRP concentrations were observed in obese patients in comparison of non-obese ones (P<0.05). There was no significant differences in total protein levels between two groups (P> 0.05). A positive correlation between CRP levels and BMI was found (r= 0.33, P= 0.003). Interestingly a negative correlation between serum albumin levels with BMI was observed (r= -0.39, P= 0.000). Conclusions: As Alterations in inflammatory markers were observed in included obese patients in comparison of non-obese one and such alterations synergize in obese patients, it is recommended that previously treated breast cancer patients, strictly control their BMI.
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Authors
Zeinab Babaei
Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran.
Hadi Parsian
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
Dariush Moslemi
Department of Radiation Oncology, Babol University of Medical Sciences, Babol, Iran.