ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Gaillardin, a sesquiterpene lactone from Inula aucheriana, inhibits the growth of human breast cancer cell lines via induction of apoptosis

Year: 1394
COI: ICBCMED11_181
Language: EnglishView: 293
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Faranak Fallahian - Cellular and Molecular Research Center, Qom university of Medical Sciences, Qom, Iran.
Maryam Hamzeloo-Moghadam - Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahmoud Aghaei - Department of Clinical Biochemistry, School of Pharmacy & Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Hossein Abdolmohammadi - Cellular and Molecular Research Center, Qom university of Medical Sciences, Qom, Iran.

Abstract:

Introduction: Medicinal plant extracts have been widely used for cancer treatment. Gaillardin is a natural sesquiterpene lactone that has recently been reported to have anticancer properties. The ability to induce apoptosis is an important property of a candidate anticancer drug, which discriminates between anticancer drugs and toxic compounds. The current study was therefore carried out to address the issue if Gaillardin is able to induce apoptosis in the breast cancer cell lines MCF-7 and MDA-MB-468 and to determine the underlying mechanism of its anticancer effects. Methods: Apoptosis induction by Gaillardin treatment was confirmed by annexin VFITC/ PI staining, and caspase-3 and-9 activation. Results: Analysis of Gaillardin-treated cells by Annexin V⁄PI staining revealed that Gaillardin, in a time and concentration-dependent manner, promotes a significant level of cell death via the apoptotic pathway. Conclusion: Taken together, these results suggest that Gaillardin inhibits growth of MCF-7 and MDA-MB-468 breast cancer cells and may potentially serve as an agent for breast cancer therapy.

Keywords:

Gaillardin , Sesquiterpene lactone , Apoptosis , Breast cancer cell lines

Paper COI Code

This Paper COI Code is ICBCMED11_181. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/726838/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Fallahian, Faranak and Hamzeloo-Moghadam, Maryam and Aghaei, Mahmoud and Abdolmohammadi, Mohammad Hossein,1394,Gaillardin, a sesquiterpene lactone from Inula aucheriana, inhibits the growth of human breast cancer cell lines via induction of apoptosis,11th International Breast Cancer Congress,Tehran,https://civilica.com/doc/726838

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم
این Paper در بخشهای موضوعی زیر دسته بندی شده است:

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: دانشگاه دولتی
Paper count: 4,768
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support