Manouchehr Fadaee - Laboratory Sciences Student, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
Amir Mohammad Zadeh - Laboratory Sciences Student, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Ghourbanpour - Laboratory Sciences Student, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
Anis Khoshkbar Sadigh - Laboratory Sciences Student, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran

Background: Shark cartilage is one of the complementary medicine, which can be used to inhibit cancerous tumors growth. There is a few information about how thehuman immune response to this matter. The aim of this study is to evaluate the effect of consumption of it on stimulating the human immune system. Search method:This article is a review paper which is done with use of scientific papers published in national and international journals and advanced search with shark , breast cancer and gamma interferon keywords and their English equivalents in Google scholar, Iran med and Pub med databases. About 75 papers were found and 12 articles among them were reviewed. Results: According to studies, 90% of studies have shown that consumption of shark cartilage in the test group increased titers of interferon gamma, TCD4 + , T-CD8 + and with direct cytotoxic effects on MCF7 tumor cells can inhibit the growth of these cells . But it did not show a significant difference in the controlled group. Conclusion: The use of shark cartilage increase strengthens of the immune system against the cancerous tumor by stimulating increasing the T lymphocytes and the production of gamma interferon.

breast cancer , cellular immunity , interfron gamma