Intravitreal Injection of Zoledronic Acid in a Rat Model of Choroidal Neovascularization
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IRAVOMED08_078
تاریخ نمایه سازی: 21 اردیبهشت 1397
Abstract:
Purpose: To determine the effects of intra vitreal zoledronic acid (IVZA) on attenuation of laser-induced choroidal neovascularization (CNV) in rats.Methods: CNV was induced in 30 pigmented rats via laser burns. Rats were divided into two groups; one group received IVZA (8 μg / 2 μL) and another group received 2 μL normal saline. Neovascularization area was quantified by lectin staining of choroidal-scleral flat mounts by using Image J software. Results: Mean CNV area in the IVZA group (30016.02) was significantly less than the controls (43935.49) (P value = 0.059).Conclusion: IVZA with dose of 8 μg / 2 μL was effective in attenuation of CNV in rats. To maximize the antiangiogenic effect of IVZA, further investigation using the maximum safe dose of IVZA should be conducted
Authors
Mohammadreza Salarbehzadi
Department of clinical sciences , Faculty of Veterinary Medicine , Science and Research Branch,Tehran,Iran
Ramin Nourinia
Ophthalmic Research center, Shahid Beheshti University of Medical Sciences,Tehran ,Iran
Mozhgan Rezaei Kanavi
Ophthalmic Research center, Shahid Beheshti University of Medical Sciences,Tehran ,Iran
Hamid Ahmadieh
Ophthalmic Research center, Shahid Beheshti University of Medical Sciences,Tehran ,Iran