Investigation of Chloride effect in connection of Pseudo oligosaccharids inhibitors to porcine pancreatic amylase

Inhibitors of alpha-amylase are proposed as potential treatment aid of diabetes and obesity. Since recognition of the effect of amino acids on joining to ligands in designing new inhibitors is so important , created interactions between PPA(porcine pancreatic amylase) with Acarbose, Acarviosine, carviosine Glucose ,Glcthiohydantoin and Pentagalloyl glucose inhibitors was examined. .In this investigatition we used of Autodock3.All of investigating inhibitors was in Active site .Interactions between enzyms and inhibitors was pi-pi and hydrogen bonds. in the examination of the effect of Foregoing inhibitors on PPA the number of available amino acids in active site are W58, H201, I235 and with analysis the effect of suger inhibitors on PPA (without، K200 ،in high rank which are E233 and E233 play important role. chloride) N301

Keywords:

diabetes , porcine pancreatic amylase , Pseudo oligosaccharids inhibitors