HIWI3 gene polymorphism and male infertility

Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

ISERB03_193

تاریخ نمایه سازی: 11 خرداد 1397

Abstract:

Background: Oligo and azoospermia as the male infertility factors can be found in one out of six couples suffered from infertility problems around the world. In general, genetic and environmental factors involved two groups of factors in male infertility. HIWI3 polymorphism has been reported as one of the genetic factors. The purpose of this study was to evaluate the association between HIWI3 rs11703684(C> T) in men with idiopathic azoospermia/oligozoospermia.Methods: In the case-control investigation, we determined genotypes of HIWI3 C> T polymorphisms by Tetra Arms-PCR technique in 100 cases with idiopathic azoospermia/oligozoospermia and 100 fertile men as control.Result: DNA analysis of the case and control groups for HIWI3 C> T polymorphism showed no significant association between two groups. Our data showed that no significant difference in the frequency of allelic polymorphism HIWI3 gene in case groups (TT: 1% -TC: 25%- CC: 74%) and control (TT: 6% -TC: 30% - CC:64%) exist (p> 0.05).Conclusion: The results suggested that C> T gene variation HIWI3 was not contributed to the genetic predisposition of male infertility

Authors

Sara Salimi

Department of Molecular Biology, Ahar Branch, Islamic Azad University, Ahar, Iran

Saeid Ghorbian

Department of Molecular Biology, Ahar Branch, Islamic Azad University, Ahar, Iran

Reza Alibakhshi

Department of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran