How Nano-micelle curcumin regresses ovarian redox system

Background: Curcumin as an antioxidant component possesses a wide range of medical characteristics. Considering contrary finding about detrimental/beneficial impacts of curcumin on male and female reproductive potential, here in present study the effect of Nano-micelle Curcumin (NMC), as more active agent, on expression of antioxidant genes was assessed.Methods: To follow-up this study, twenty-four mature female Wistar rats were assigned into control and test groups. The animals in test group were subdivided into 7.5 mg/kg b.w -1, 15 mg/kg b.w -1, 30 mg/kg b.w -1NMC-received groups. The NMC was administrated orally by gavage for 48 days. Due to experimental study the animals were selected at ovulation stage by using pap-smear test and the expression of redox antioxidant genes including Mn-superoxide dismutase (SOD), CuZn-SOD and glutathione peroxidase (GSH-Px) was examined.Result: The CuZn-SOD mRNA level was increased in 15 mg/kg b.w -1 and the animals in 30 mg/kg b.w -1 NMC-received group exhibited similar pattern with control group for Mn-SOD mRNA level. The animals in 15 mg/kg b.w -1 showed enhanced GSH-Px expression versus other groups. Finally, no GSH-Px as well as SOD subtypes were determined in those animals in 7.5 mg/kg b.w -1 NMC-received group.Conclusion: Our data showed that, the NMC significantly affects the ovarian redox enzymes expression in intact female rats. More studies are needed to show the NMC-induced side effects against ovarian antioxidant potential.

Keywords:

CuZn-superoxide dismutase , Glutathione peroxidase , Mn-superoxide dismutase. , Ovarian tissue , Nano-micelle Curcumin