The association between matrix metalloproteinases-2, 9 and endothelial dysfunction with echocardiographic findings in children with end stage renal disease

Introduction: Cardiovascular disease (CVD) is the most likely cause of mortality in children with end stage renal disease (ESRD). Matrix metalloproteinases-2, 9 (MMP-2, 9), and endothelial dysfunction could contribute in CVD development in such patients. The aim of this study was to evaluate the association between MMP-2, 9 and endothelial dysfunction markers (sE-selectin and brachial flow mediated dilatation (FMD)) with echocardiographic findings in children with ESRD.Methods:31 children with ESRD and 18 healthy age- and sex- matched subjects as controls were recruited. Serum levels of MMP-2,9 and sE-selectin were measured. Brachial FMD and echocardiographic parameters were evaluated.Results: Serum levels of MMP-2, 9, andsE-selectin were significantly higher in patients than controls.The means of brachial FMD, ejection fraction (EF), and E/A ratio were significantly lower in patients than controls. Children with ESRD had higher means of left ventricular end systolic diameter (LVESD) and left ventricular end diastolic diameter (LVEDD) than controls. MMP-2 was correlated with EF, and E/A ratio negatively and was positively correlated with LVES, and LVED. MMP-9 was inversely correlated with EF.Conclusion: MMP-2, 9 were associated with cardiac abnormalities in children with ESRD. We didn t find correlation between endothelial dysfunction markers and echocardiographic parameters.

Keywords:

Matrix metalloproteinase-2 (MMP-2) , Matrix metalloproteinase-9 (MMP-9) , sE-selectin , Flow mediated dilatation (FMD) , End stage renal disease (ESRD) , Cardiovascular disease (CVD) , Children , Echocardiography