Sperm DNA Fragmentation and Antioxidant Therapy in Infertile Men With Varicocele
Publish place: Fourth International Congress on Reproduction
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
View: 474
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد
- Certificate
- من نویسنده این مقاله هستم
این Paper در بخشهای موضوعی زیر دسته بندی شده است:
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
ISERB04_071
تاریخ نمایه سازی: 16 تیر 1397
Abstract:
The Varicocele (VCL) has been implicated as a major cause of male infertility in in 35% of men with primary Infertility and in up to 80% of men with secondary infertility. A number of studies have demonstrated increased levels of ROS and reduced total antioxidant capacity (TAC) in men with a clinical diagnosis of varicocele. These reports suggest that, the sperm dysfunction in varicocele patients may be in part related to oxidative stress and as a negative predictor of fertility potential men with DNA damage higher that 30% have very low potential for in-vitro and in-vivo fertility. In line with this issue, several positive results were obserened after oral administration of various antioxidant agents/chemicals in varicoceles with moderate DNA damage. For instance, the administration of glutathione (GSH), every day for 2 months, could significantly boost sperm count and motility in men with VCL. In other study, the carnitine and acetyl-ℓ-carnitine for 6 months could fairly enhance the sperm parameters, including DNAintegrity. In another study, 20 infertile patients with grade I varicocele were given multivitamins (L-Carnitine, vitamin C, coenzyme Q10, vitamin E, vitamin B9, vitamin B12, zinc, selenium) daily, for 3 months and the results showed increased sperm basic parameters and a decrease in sperm DNA fragmentation. Morover, A complex ofacetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid have been shown to up-regulate sperm quality even after varicocelectomy. Thus, the management of DNA damage in varicoceles is also challenging and antioxidant therapy in patients with VCL, proportionately can improve semen quality.
Keywords:
Authors
Mazdak Razi
Department of Basic Science, Faculty of Veterinar y Medicine, Urmia University