The Effect of Cinnamon Extract on Histological Parameters in Hyperlipidemic Male Rats

Backgournd: One of the major issues in medical sciences is infertility or fertility decline. According to previous studies, obesity and hyperlipidemia are the among of the primary causes of infertility in men. recent studies have shown that cinnamon consumption significantly affects lipid profiles. The aim of this study was to evaluate the effect of cinnamon extract on histological parameters in hyperlipidemic male rats.Methods: In this experimental study, 24 male Wistar rats were divided into 4 groups, control, sham and cinnamon groups receiving 130 and 260 mg of cinnamon. All groups except control received 20% high fat diet for 8 weeks to induce hyperlipidemia. Then, cinnamon groups received cinnamon extracts for 6 weeks intraperitoneally (IP). In the 14th week, under anesthesia, the animals were underwent testicular surgery. Then, lipid profile and histological tests were evaluated. Results: The results of this study showed that cinnamon extract improved lipid profile. The histology results in the treatment group indicated an increase in the number of cells in the testicular seminal tubules and an increase in the number of cells and spermatogenesis layers (P<0.001). Conclusion: Given that cinnamon has a positive effect on testicular histology, it is suggested that cinnamon could be added to the diet of people with hyperlipidemia.