Crab Shell Extract Ameliorates Reproductive Parameters in Diabetic Rats
Publish place: Fourth International Congress on Reproduction
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISERB04_148
تاریخ نمایه سازی: 16 تیر 1397
Abstract:
Backgournd: Crab Shell (CS) has been used as a promising nutritional and medical compound in traditional medicine. Diabetes is a complex oxidative stress dependent disease, and CS showed antioxidant properties. The aim of present study was to investigate the effect of CS extract on sperm parameters and testes histopathology in diabetic rats.Methods: In this experimental study, forty Wistar male rats (200±15) were used in 5 groups (n=8); including control, diabetic and diabetic treated (100, 200 and 400 mg/kg of CS) rats. Diabetes induced using a single dose (50 mg/kg) of streptozotocin (STZ) interaperitonealy and three days later, blood glucose level greater than 250 mg/dl was considered diabetic. Treatments with CS were started for 14 days. The fasting blood glucose, testosterone level, testes weight, sperm viability, count and motility were assessed. Also, testes were processed for histological studies. Data were analyzed using SPSS software and one way ANOVA methods.Results: Sperm count, motility and testosterone levels increased significantly (p=0.000) in CS treated diabetic rats in a dose-depended manner, while the number of immotile sperm (p= 0.017) decreased. CS also decreased fasting blood glucose.Conclusion: CS improves Reproductive parameters and protects testicular tissue against the oxidative stress damage by diabetes in rats.
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Authors
Mozafar Khazaei
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences
Atefeh Ansarian,
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences
Mohammad rasool Khazaei
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences