Crab Shell Extract Ameliorates Reproductive Parameters in Diabetic Rats

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
View: 553

نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

  • Certificate
  • من نویسنده این مقاله هستم

این Paper در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

ISERB04_148

تاریخ نمایه سازی: 16 تیر 1397

Abstract:

Backgournd: Crab Shell (CS) has been used as a promising nutritional and medical compound in traditional medicine. Diabetes is a complex oxidative stress dependent disease, and CS showed antioxidant properties. The aim of present study was to investigate the effect of CS extract on sperm parameters and testes histopathology in diabetic rats.Methods: In this experimental study, forty Wistar male rats (200±15) were used in 5 groups (n=8); including control, diabetic and diabetic treated (100, 200 and 400 mg/kg of CS) rats. Diabetes induced using a single dose (50 mg/kg) of streptozotocin (STZ) interaperitonealy and three days later, blood glucose level greater than 250 mg/dl was considered diabetic. Treatments with CS were started for 14 days. The fasting blood glucose, testosterone level, testes weight, sperm viability, count and motility were assessed. Also, testes were processed for histological studies. Data were analyzed using SPSS software and one way ANOVA methods.Results: Sperm count, motility and testosterone levels increased significantly (p=0.000) in CS treated diabetic rats in a dose-depended manner, while the number of immotile sperm (p= 0.017) decreased. CS also decreased fasting blood glucose.Conclusion: CS improves Reproductive parameters and protects testicular tissue against the oxidative stress damage by diabetes in rats.  

Authors

Mozafar Khazaei

Fertility and Infertility Research Center, Kermanshah University of Medical Sciences

Atefeh Ansarian,

Fertility and Infertility Research Center, Kermanshah University of Medical Sciences

Mohammad rasool Khazaei

Fertility and Infertility Research Center, Kermanshah University of Medical Sciences