Antioxidant Therapy of Asthenozoospermia

Backgournd: Infertility has involved around 12 % of all men around the world. The prognosis of male infertility is predicated in large part on conventional semen evaluation. Asthenozoospermia is one of the most important causes of male infertility. Oxidative stress is one of the important mediators in numerous etiologies of male infertility. Oxidative stress occurs while reactive oxygen species (ROS) and the ranges of other free radicals are substantially expanded or antioxidant levels are appreciably decreased.Aim of study: Many urologists prescribe oral antioxidant therapy for men. The rationale for recommending oral antioxidant therapy is based on the assumption that seminal oxidative stress is due in constituent to an insufficiency in seminal antioxidants and the lack of serious side effects related to antioxidant therapy. Therefore, we used an antioxidant supplement for treating infertility for Iranian men.Material & Methods: We used antioxidant supplementation of Vitamin E, Folic acid and Selenium for 20 men with asthenozoospermia for a three months period. This research project was approved by the Ethics Committee of Avicenna Research Institute. Patients entered the study with written consent.Results: After 3 months of receiving complementary pills, the sperm motility slightly increased in these individuals. There was even a positive effect on other parameters of sperm. However, the Progressive motility of sperm in this group of patients was not statistically significant. Conclusion: The use of antioxidants is effective in treating asthenozoospermia disease, but different antioxidant supplements should be evaluated with different doses to achieve the best results.

Keywords:

Male Infertility , Antioxidant Therapy , Asthenozoospermia